The launch marked the first time SpaceX used previously flown hardware - a Falcon 9 and Dragon capsule - to send cargo up to the ISS, signifying NASA's confidence in the viability and reliability of its reusable launch vehicles.
This launch will be the first time that the company flies a used Dragon capsule as well as a used Falcon 9 capsule for NASA.
At 10:36 a.m. EDT Elon Musk's 17th, and potentially most important Falcon-9 launch of the season took flight from the recently refurbished Launch Complex 40, in Florida's Cape Canaveral Air Force Station.
And now that the pad is back in action, it paves the way for SpaceX to launch the company's next big rocket, the Falcon Heavy - a larger version of its Falcon 9 that includes three rocket cores.
Since successfully delivering the Koreasat-5A satellite in October, SpaceX's launch schedule has had a long hiatus of over a month. Yet with a reused rocket and capsule, the mission's price tag is assumed to be much cheaper than their status quo.
SpaceX landed its first-stage booster back on land at Cape Canaveral Air Force Station.
SpaceX's Dragon cargo craft flies away from the upper stage of its Falcon 9 rocket after arriving in orbit, kicking off a two-day pursuit of the International Space Station.
The payload is the Dragon spacecraft with 4,800 pounds of cargo including science research space station.
NASA's ISS program manager Kirk Shireman said rocket experts from around the agency had reviewed safety for the mission, and that re-used components were seen as no more risky than new ones.
The Dragon reaches the space station Sunday. This marks SpaceX's 20th landing to-date. Moving forward, NASA says it will make the decision to fly used rockets for resupply missions on a case-by-case basis.
It was one of the Elon Musk-founded company's most lovely landings to date, taking place in clear blue skies at SpaceX's Landing Zone-1 back on land in Cape Canaveral, Florida.
Eventually, SpaceX hopes to be able to land and turn around rockets for reuse in under 24 hours, to help it service commercial clients quickly and effectively. There might be some Christmas presents in there, too.