Their last meeting at Estádio do Dragão occurred back in 2007 in a Champions League group stage fixture that ended in a 1-1 draw. Averaging four goals per game in their six qualifying matches, Liverpool's Roberto Firmino is the second top scorer in the competition this year.
I have seen some of the highest profile players in world football quaking in their boots on big European nights at Anfield and the noise and passion you expect on a big Champions League nights in that stadium will be ramped up a few more notches with the new stand allowing so many more people to get into game.
Porto coach Sergio Conceicao congratulated compatriot Carlos Carvalhal on masterminding Swansea's recent victory over Liverpool but admits facing the Reds in the Champions League is a different prospect.
"He was involved in the game, was open and it was just a good performance from him".
Nonetheless, the North African may yet be Africa's best bet for a new European Cup victor, if, of course, Real can put their domestic troubles behind them against a PSG side desperate to make amends for last year's capitulation against Barcelona.
For a team which has scored 94 times this season, there is every chance that Porto's defence and their current number one Jose Sa face an uncomfortable couple of matches. It has been almost a decade since the last time Liverpool got past the Round of 16. "For all goalkeepers it is the same, they need that [confidence]".
"I don't know if Porto are going to be afraid but we are going to make their life hard and make them suffer", said Firmino, who has scored 20 goals in all competitions, including six in the Champions League.
Salah will be supported by Sadio Mane, and while the Senegal worldwide has struggled to replicate his early-season form in recent fixtures - finding himself overshadowed by the North African and Roberto Firmino - he remains one of the competition's brightest attackers.
The Dragoes are yet to lose a single game in the Portuguese top-flight this season, and now hold a hugely impressive +43 goal difference.
The man in Real's goal for both matches was Casillas. "And of course we as a team we will never do that", he said. Loris needs to play all games his gonna be the next Dea! "If I play a good game then the goals will appear".
Liverpool manager Jurgen Klopp has warned his side not to underestimate Porto when the two sides meet in the first leg of their Champions League last 16 tie tonight. Klopp too has time and again expressed his happiness on having the Brazilian attacker at his disposal and said that Coutinho's departure has brought the best out of Firmino.