"We've all heard stories of a friend who went on one diet - it worked great - and then another friend tried the same diet, and it didn't work at all", he said. The reason being all are varied, and we are just commencing to comprehend the basis for this diversity.
"Also, we advised them to diet in a way that didn't make them feel hungry or deprived - otherwise it's hard to maintain the diet in the long run", he said. Gardner and colleagues now want to investigate the microbiome, epigenetics, or a different gene expression pattern they've yet to figure out for clues that might explain the drastic variability. PPARG is involved with how the body metabolizes fats. However, there was a lot of weight loss variability among people for each type of diet, which suggests that what works for some people won't necessarily work the same way for others.
The researchers also tested how people respond to a big dose of sugar.
It's possible that the study failed to find a difference in weight loss with either diet based on genotypes at least in part because participants didn't really follow the instructions for their assigned diet, said Susan Roberts of the USDA Nutrition Center on Aging at Tufts University in Boston. They divided them into three categories - those with gene variants sensitive to dietary fats, those sensitive to carbs, and those who have no such sensitivities - and gave each one the appropriate diet.
"By becoming engrossed in counting calories and restricting our food intake, which is often what a diet requires us to do, it means becoming more and more confused in regards to what it means to be healthy". Nobody should have foods with refined sugar. Now, I honestly think they likely exaggerated the caloric restriction.
The participants began by limiting their daily carbohydrate or fat intake to around 20 grams for the first eight weeks. A hamburger patty has about 17 grams of fat and a tablespoon of butter has 12 grams; one-third of a cup of pasta has 15 grams of carbohydrate while a 12 ounce cola soft drink has 39 grams of carbs.
After a year, 200 of the volunteers had dropped out. Within each diet group, there was an individual who lost as much as 60 lbs. Similarly, a few women whose DNA did not "match" went through a divorce or other upheaval, ate for emotional comfort, gained weight, and made the mismatched group look terrible-a reminder that so many emotional, economic, metabolic, social, and other forces affect someone's chance of losing weight that the effect of genes gets lost in the noise. However, in this study, the researchers calculated each person's genotype patterns and found that the type of diet did not make any difference in the amount of weight the individuals lost. Individuals in both groups also showed improvements in other important health markers such as reduced body fat, lower blood sugar, improved blood pressure levels and decreased waist size. Gardner told Live Science.
"One both sides, we heard from people who had lost the most weight that we had helped them change their relationship to food, and that now they were more thoughtful about how they ate".