Heynckes, who checked out from his previous stint as Bayern boss as a treble victor in 2013, has his team chasing another trio of titles this campaign.
The German manager praised Sevilla's Argentinean midfielder, Ever Banega, saying "Banega is a great player".
Sevilla did find the net once when the teams met last week on Spanish soil, Pablo Sarabia putting them ahead in the first half, but were eventually beaten by a pair of deflected goals.
"They will certainly go on the offensive", said Heynckes. "When they lost in previous years to Real Madrid, Barcelona and Atletico Madrid a lot of the goals were on the counter attack", Hargreaves told BT Sport.
- In the history of the competition, there have been 312 occasions of the home team losing the first leg of a knockout tie - only six of those sides have progressed.
"When he took over, Jupp said that it would be hard to make up the five points - now we have more than 20 on Dortmund", beamed Rummenigge.
The Champions League match between Bayern Munich and Sevilla will be broadcast live online.
Elsewhere, Bayern Munich will host Sevilla in an intriguing contest on Wednesday after the first leg in Spain which Bayern Munich won by 2-1.
The report claims that Bayern are particularly interested as they are set to lose both Robben and Ribery in the summer, as both out of contract and they are 34 and 35 respectively. "With two away goals already, I have to say that one is over".
"They (Sevilla) did brilliantly in Manchester and we know we have to perform".
Crucially though, several Bayern players will need to be extremely disciplined so as to be safe from suspension, with the likes of Jerome Boateng, Joshua Kimmich, Robert Lewandowski, Franck Ribery, Sebastian Rudy and Corentin Tolisso just one booking away from incurring a one-match ban. James Rodriguez has chipped in as well.