Turkey on April 14 welcomed Western strikes targeting Syrian President Bashar al-Assad's regime as an "appropriate response" in retaliation for a suspected chemical attack that left dozens dead.
Yildirim on Friday again condemned the "heinous" the attack in Douma and said the perpetrators should "pay a price".
The Assad regime has been blamed for a chemical attack Saturday night in the city of Douma in Eastern Ghouta, killing 78 civilians and injuring hundreds of others, according to the White Helmets civil defense agency.
Turkish President Recep Erdogan has warned against further escalation in Syria in a phone talk with UK PM Theresa May.
Government spokesman and Deputy Prime Minister Bekir Bozdağ said the USA did not use the Incirlik air base located in southern Adana province in the attacks.
Earlier Saturday, the USA, along with its allies Britain and France, launched missile strikes on Syria over allegations that the Syrian government used poison gas in an attack on the rebel-held town of Douma near the capital Damascus on April 7.
Erdogan told May that the only way to long-lasting peace in Syria was a "political solution", the source added.
Turkey was informed of the attack in advance, Bozdag said in a tweet on his twitter account. The Turkish leader also emphasised the importance of de-escalating the tension in the region. "The Incirlik base was not used in the attack".
"It is not all about the chemicals, more people were slaughtered previously by conventional weapons", he stressed, calling on world countries to put the future of all kinds of weapons on the table for discussions in detail.
"The conscience of the global community is in no doubt about that".