Female runners with naturally high testosterone levels will have to race against men or switch events unless they take medication under new IAAF rules which begin in November.
Media in the United Kingdom and South Africa on Wednesday published sections of the report ahead of its official release, revealing that the new hyperandrogenism regulations would include a separate female classification to be known as an Athlete with Differences of Sexual Development (DSD).
"We want athletes to be incentivised to make the huge commitment and sacrifice required to excel in the sport‚ and to inspire new generations to join the sport and aspire to the same excellence‚" said IAAF president Sebastian Coe in a statement.
South Africa's Caster Semenya will face a tough decision if she chooses to compete at another global sports meet.
However‚ the regulations‚ expected to be confirmed on Thursday‚ may end up in the Court of Arbitration for Sport (CAS), should Semenya challenge them.
It has also seen backlash spread across social media, with users calling the regulation "sexist".
Women with elevated testosterone must reduce their level for "six months (e.g., by use of hormonal contraceptives)" before being eligible to run, and maintain that lowered level.
When the IAAF limit was in place, Semenya's times slowed but since its suspension, she has returned to dominance in the women's 800 meters. Two years earlier, Semenya clocked a 1-minute, 55-second time to win her first world title as a teenager in Berlin.
Similar restrictions brought in by athletics' world governing body, the International Association of Athletics Federations, were suspended following a legal challenge by the Indian sprinter Dutee Chand in 2015.
Semenya, 27, has won gold medals in the 800-metre race in both the 2012 and 2016 Olympics for South Africa.
However, 100m, 200m and 100m hurdles are exempt, as a race over one mile and field events.
Semenya's domination of the female middle-distance track is under threat, after the IAAF approved controversial rule changes for athletes with hyperandrogenism on Thursday, at the same time presenting female athletes with the condition - Semenya in particular - with an uncompromising ultimatum.
'As the International Federation for our sport, we have a responsibility to ensure a level playing field for athletes.
The ruling seems to target the hyperandrogenic Caster Semenya of South Africa, who is essentially unbeatable in the 800m against women when allowed to compete at her naturally occurring hormone levels.
I think the IAAF is setting a kind of standard in terms of how they differentiate between men and women and what is acceptable.