History books will show that Anderson came out on top in a 7-6 (6) 6-7 (5) 6-7 (9) 6-4 26-24 epic that lasted six hours and 36 minutes - the longest ever semi-final at Wimbledon - but those numbers fail to illustrate the astonishing feats of endurance shown by the two gladiators on the most famous stage in tennis.
It's not the first time that Isner has played to a marathon match - back in 2010, he defeated Nicolas Mahut 6-4, 3-6, 6-7 (7), 7-6 (7), 70-68 in the first round at Wimbledon in a match that lasted over 11 hours and was played over three days.
"You feel like it's a draw between the two of us, but somebody has to win".
"John's such a great guy".
"I feel pretty awful", Isner said afterward.
"If I was on the opposite (losing) side I don't know how you take it".
"I apologise if I´m not more excited right now".
"But at the same time, I'm through to the final". They combined for 102 aces, 53 by Isner, 49 by Anderson.
He had also gone five sets to beat eight-time champion Roger Federer in the quarter-finals, winning the decider 13-11.
"Very, very happy to be in this position right now in the semi-finals".
Games went with serve in the third set with Nadal failing to convert three set points in the tie-break, allowing Djokovic to take the set when his opponent netted a backhand.
The American's response was immediate, breaking straight back in the next game as Anderson served for a two sets to love lead at 5-3.
Now the superstar quartet 's reign is under siege from serving bombers Isner and Anderson, who have rocketed down some 284 untouchable deliveries in their first-time forays to the final four at The All England Club.
The 33-year-old American´s composure wasn´t helped by a delay caused by a ball boy slipping and falling. Because it was so late, the All England Club shut the retractable roof above the main stadium between the matches and turned on the arena's artificial lights. The other three majors all play out the fifth set until the victor is ahead by two games. Isner wasted a set point in the opener. South African-born Kevin Curren contested the 1985 final but he had become a USA citizen by then.
With a spot in the Wimbledon final on the line, the two power players beat each other to a standstill in a match that stretched nearly seven hours.
Between them, three-times champion Djokovic, Nadal, fellow dual victor Andy Murray and dethroned eight-times king Roger Federer have won every men's singles crown since 2003.
Anderson eventually emerged victorious and will face the victor of Djokovic vs Nadal, who is not likely to be decided until tomorrow. He will take on the victor of the Djokovic-Nadal match in Sunday's final.
He is chasing an 18th Grand Slam title which would put him just two behind Federer.