Jurgen Klopp has handed new signing Alisson Becker his debut as the Brazilian worldwide goalkeeper starts between the sticks against the Serie A giants while Nathaniel Clyne, Joe Gomez and Andrew Roberton join Virgil van Dijk in defence.
Liverpool signed the 25-year-old Brazil global from Roma, smashing the world record for a keeper in a deal worth £68m.
Liverpool FC started their summer spending with the £39m addition of Brazil worldwide Fabinho from Ligue 1 side AS Monaco.
Jurgen Klopp said: "It's pretty likely [he'll make his debut]".
Of Keita, with who Liverpool had a deal set up 12 months ago, Klopp acknowledged: "We have got him because of the player he is, and now we have to let him adapt to our system".
Last season, while each of the three main strikers scored more than 20 goals each - and Salah was the Premier League's leading marksmen - no other Liverpool player other than the departed Philippe Coutinho, notched more than six across competitions.
The German first threw the ball directly out to Karim Benzema for the game's opener, before fumbling Gareth Bale's shot from range to give Real their 3-1 lead.
The club have already baulked at paying Salomon Rondon's £16.5m release clause so a move for the Liverpool forward does seem unlikely at this stage. He obviously has a real presence, he's smart, he's very nice and it's good to have him around.
Liverpool face West Ham United in their first league fixture on August 12.
However, Liverpool want £12m from clubs interested in Mignolet. "What it means for the league we will see".
Since linking up with his new Liverpool teammates in France, there has been speculation over what number Alisson would wear this season.
"I hope I can help and bring something extra to the team".