"I will say", Neville continued, "there is something rotten to the core about the way the club is operating and it has to be coming from the top".
Poor performances have been compounded by off-field problems during an uncomfortable start to the season at Old Trafford, with the relationship between Mourinho and star midfielder Paul Pogba creating unwanted headlines.
But, once again, Mourinho said this would be a "difficult season" - a tune he has been singing since the pre-season tour of the United States.
Former Manchester United captain Gary Neville has blasted a reported decision to sack Jose Mourinho as "an absolute disgrace".
In their next six matches after the break, United play Chelsea, Juventus twice, and champions Manchester City.
This week Mourinho told his players that the badge on the front of the shirt is as important as the name of the back, having expressed his concern that some care about United's issues more than others. I think that is clear. "I used to love it". A better team would have picked United off and buried them to make any comeback impossible.
While the Magpies boss' tactics may have not racked up the points, by adapting a defensive style when playing the so-called big sides in the league, he frustrates and forces them to play to their best to get any sort of a positive result. When you are in your own city, your own stadium, and you have 75 minutes minimum on the bus, I think that this is quite hard to accept.
The former World Cup victor could also be key in unlocking the potential of fellow French man Paul Pogba, whom Mourinho reportedly fell out with amidst a string of poor performances.
"And the players have to take their share of the blame because they can put the effort in like they did in the second half against Newcastle". I love that football club, I absolutely love it to death, it's been my life, it's given me everything, and I'm not turning on my football club, (but) I have to say something has to change and it isn't the manager, it's above that. The people in the boardroom who are overseeing the football operation are nowhere near good enough.