Liverpool might come up against the Belgian playmaker on Sunday if he passes late fitness tests and will nearly definitely have a place on the bench even if he is unable to start the game at Anfield.
"It's very tough, probably the toughest away game of the season in the Premier League", the Germany worldwide told ESPN FC. In the first Champions League game we made a good performance except at the end of the first half.
"We don't save lives, we don't create anything, we are not good in surgeries, we are only good in football".
Liverpool's home form in the Premier League and their excellent recent results against Manchester City explain their status as slight favourites here.
"The reason why last time he didn't [start] - the only time he didn't [start] - was for another reason, a tactical movement, so Kyle Walker can attack more on the right side than him", Guardiola said at a news conference.
The Blues have encountered problems in stopping the Reds in recent seasons with Jurgen Klopp's side coming out on top in the Champions League last term - and Guardiola has praised the Reds. I'll therefore go for Over 3.5 Goals at [2.6].
Meanwhile, Liverpool boss Jurgen Klopp believes Wednesday's disappointing defeat at Napoli could boost his side's chances of beating City.
Pep Guardiola has added £60million Riyad Mahrez to the squad that won the Premier League with a record number of points and goals last season. Against Guardiola, Klopp tends to demand a faster, more direct approach to try to exploit City's high defensive line.
On the City side of things, Sergio Aguero has been passed fit, and is [2.22], but bear in mind he has never scored at Anfield in 11 attempts for City and Atletico Madrid.
"That's not discarding Chelsea, Tottenham, Manchester United, Arsenal or whoever else is going to be up there, but we're both going into the game undefeated and hopefully we can come out on top".
"I was surprised the front three were playing".
City last visited Anfield in April for the first leg of a Champions League quarterfinal and that game was somewhat overshadowed by events prior to kick-off.
"I grew up in a time when Boris Becker and Michael Stich were the best tennis players in Germany and maybe for a few years in the world", Klopp explains.