Vice President Mike Pence presided over the final vote.
Dozens of protesters attempted to march up the Capitol's east steps, with some being arrested by Capitol Police amid chants of "no justice, no peace". The vote unfolded with protesters shouting from the gallery. Protesters could nearly immediately be heard when Vice President Mike Pence began to oversee the voting.
Manchin's decision on Kavanaugh had more political expedience behind it: he announced his support for Kavanaugh only after Sen. A third accuser, Julie Swetnick, also claims she was assaulted by Kavanaugh. "In other words, people thinking of the court as not politically divided in the same way, as not an extension of politics, but instead somehow above the fray", she said. However, based on all of the information I have available to me, including the recently completed Federal Bureau of Investigation report, I have found Judge Kavanaugh to be a qualified jurist who will follow the Constitution and determine cases based on the legal findings before him. "... Judge Kavanaugh was so upset he was not thinking of his appearance".
But he said he was quickly welcomed by his eight fellow justices.
Democrats also raised concerns about his views on executive power, and whether he was selected by President Trump because he would be a sure-fire vote to protect Trump from the various investigations and lawsuits surrounding his presidency.
Trump, flying to Kansas for a political rally, flashed a thumbs-up gesture when the tally was announced and praised Kavanaugh for being "able to withstand this frightful, awful attack by the Democrats".
In a twist, Murkowski voted "present" Saturday as a courtesy to Republican Kavanaugh supporter Steve Daines, who was to walk his daughter down the aisle at her wedding in Montana.
Ten law professors from Iowa opposed Kavanaugh's confirmation based on his combative testimony September 27, signing onto a letter signed by more than 2,400 legal scholars that was sent to the Senate Thursday. His record as a member of the D.C. Circuit Court shows he has voted with the majority of that court 97 percent of the time, and his reasoning has been adopted by the U.S. Supreme Court 13 times.
Democratic leader Chuck Schumer of NY looked ahead to November, appealing to voters beyond the Senate chamber: "Change must come from where change in America always begins: the ballot box".
Mr McConnell said at a press conference that putting Mr Kavanaugh on the court "was about treating someone fairly". Because senators confirmed Kavanaugh to the court, she hoped the public would take action in future elections.
"They want a court that will fight to uphold Citizens United and allow unlimited money in our political system, but not for a loving same-sex couple to join together in marriage".
The Women's March group took credit for the protests on Twitter as they were unfolding. That was followed by a letter submitted to the Judiciary Committee by one of Ford's longterm ex-boyfriends, who said in their six years of dating, she never showed any fear of flying - even as they flew together on a plane - never demonstrated fear of enclosed spaces, and never once mentioned any previous sexual assault.
"Like so many millions of Americans, I was moved by Dr. Blasey Ford's testimony". "Both oaths will be administered so that [Kavanaugh] can begin to participate in the work of the Court immediately", the court said in a statement prior to the swearing in.
"Judge Kavanaugh is without doubt one of the most qualified people to be nominated to America's highest court. It's crucial that we listen to their voices and not dismiss or ignore them".
On Friday, the Senate had voted 51-49 to close the debate and to proceed to the confirmation vote itself on Saturday.
The vote on confirming Kavanaugh as an associate justice will begin at roughly 3:30 p.m., and senators have been advised to be in their seats by the time the historic roll call begins.