Mrs Trump insisted that talk about her husband's alleged infidelities do not concern her, despite him being accused of many affairs.
The US First Lady claimed people are simply spreading rumours about her marriage during an interview with ABC News while touring Africa.
"I'm a mother and a first lady, and I have much more important things to think about and to do", she added. "I know people like to speculate and the media likes to speculate about our marriage".
"Yeah, it's not always pleasant, of course", admits the 48-year-old.
Asked if she loves President Donald Trump, she said: "Yes, we are fine".
"She believes her husband, and she knows it's untrue", Giuliani said then.
"Media likes to speculate about our marriage", she added, like she meant it to sting. It is not always correct stuff'.
Asked why Giuliani would have made that claim about her, she retorted: "I don't know".
Melania also said there are people now in the White House she doesn't trust and who do not have her husband's best interests in mind. That one was too easy: "I don't know; you have to ask him", the First Lady replied. She asked Llamas, "Is it possible that she's not concerned with his mistresses because she was one of them?"
"It is not a concern or focus of mine".
Again she questioned the media for the coverage that circulated when news of the alleged affair broke.
She gave a surprise answer to why she chose to fight against cyber-bullying with her "Be Best" campaign.
She has one sister, Ines, who is reported to live in NY and work as an artist. "I am enjoying it".
HollywoodLife reached out to the first lady's spokesperson for comment, but did not immediately hear back.
She met Pope Francis as part of a foreign tour with her husband and stepdaughter Ivanka past year.