First the bowlers restricted the visitors to a paltry 104 then the top-order batsmen played handsomely to wrap up the issue in just 15 overs.
Jadeja, who was named man-of-the-match, polished off the West Indies' tail and India did not need the customary break after end of the first innings to get past their target.
The return of Jasprit Bumrah and Bhuvneshwar Kumar has intensified Indian pace attack while youngster Khaleel Ahmed also found his form in the 4th ODI where he picked three key wickets and dismantled West Indies batting.
India opener Dhawan's run of poor scores continued as he chopped on a delivery from Thomas to be out for four, going through the five-match series without a half-century.
Jason Holder, the Windies captain, confirmed the development while mentioning the personnel changes at the toss of the fifth ODI in Thiruvananthapuram.
The Board of Control for Cricket in India (BCCI) had earlier announced the team India squad for T20 Internationals against West Indies and Australia. While India was chasing 105 runs, they lost their first wicket as Shikhar Dhawan has to depart in the second over of the match.
Any semblance of hope West Indies had was over when Holder allowed an edge from Kohli to burst through his hands at first slip when the batsman, who scored three consecutive centuries in the series, had made only four.
The Indian run-machine became the quickest to 10,000 ODI runs in his 205th innings in Visakhapatnam ODI that ended in a tie last week. The match start time is 1:30 PM IST.
Along with another T20 stalwart Kieron Pollard and five others, Brathwaite trained hard with the first T20 global against India starting November 4.
TV UMPIRE: I.J. Gould (England). India won by six runs.
MAN-OF-THE-MATCH: Ravindra Jadeja.